Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking
نویسندگان
چکیده
منابع مشابه
Cetuximab/C225-induced intracellular trafficking of epidermal growth factor receptor.
The monoclonal antibody C225 interacts with the ectodomain of the epidermal growth factor (EGF) receptor (EGFR) to block ligand binding and initiates receptor endocytosis and intracellular trafficking. The data herein show that C225-dependent EGFR trafficking relocalizes the receptor to the endoplasmic reticulum (ER) and nucleus. This mechanism, which also involves interaction of the C225-inter...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2019
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2019.10.015